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It has been reported that some effects can be felt when consuming the caapi vine alone, but that DMT-containing plants (such as Psychotria) remain inactive when drunk as an infusion without a source of monoamine oxidase inhibitor (MAOI) such as B. caapi. It is unclear how indigenous people discovered the hallucinogenic properties of these two plants used combined in the ayahuasca drink.


Many indigenous Amazonian people say they received the instructions directly from plants and plant spirits. Scientific Name : banisteriopsis caapi, Common Names in the Amazon: ayahuasca; yagé; bejuco; caapi; nucnu huasca; shimbaya huasca; nishi; oni; népe; xono; datém; kamarampi; pindé; natema; iona; mii; shillinto; nepi. Over 90 different indigenous tribes in the Amazon Rainforest have developed healing traditions based on the use of ayahuasca.


This number becomes even more impressive when one considers the fact that many of these tribes live thousands of miles apart and would appear to have never had contact with each other. Within the philosophy of each tribe, one point remains consistent, which is that they originally learned about ayahuasca and the science of plant medicine from the plants themselves. Both the plant and the medicine prepared from it are called ‘Ayahuasca’.


What is Ayahuasca?

The word “Ayahuasca” refers to a medicinal brew with the main ingredient being the ayahuasca vine (banisteriopsis caapi). The vine is cooked, usually in combination with at least one other admixture plant, to produce a brown liquid that is consumed in healing ceremonies led by Amazonian healers, called ayahuasqueros (curanderos). The effects of the brew vary greatly depending on which admixture plants are used in its preparation, how the curandero runs the healing ceremony, and a number of more complex aspects that are a bit of a mystery.

The admixture plants most often used are the leaves of chacruna (Psychotria viridis) and yagé; also known as chaliponga, chagraponga, and huambisa (Diplopterys cabrerana). Ayahuasca is known and used throughout Perú, Ecuador, Colombia, Bolivia, and western Brazil. The use of ayahuasca is rapidly gaining awareness and acceptance throughout the world thanks to retreat programs and organized religious movements such as Santo Daime and the União do Vegetal (UDV), which won a supreme court decision for the right of members to use the sacred medicine in ceremonies in the United States.

Ayahuasca has been used in the Peruvian Amazon for millennia, long before the Spanish came to Peru, before the Incan Empire was formed, and before history. The oldest known object related to the use of ayahuasca is a ceremonial cup which dates to a culture that ended in the year 50 A.D. Hewn out of stone with engraved ornamentation, it was discovered in Ecuador and currently rests at the Ethnological Museum of the Central University (Quito, Ecuador). In the Peruvian Amazon, its use dates back much further.

Chemically speaking, the medicine usually contains both beta-carboline and tryptamine alkaloids.  However, some indigenous Amazonian cultures, like the Yahua, prepare their ceremonial brew using only the ayahuasca vine. The ayahuasca vine contains beta-carbolines (harmine, harmaline, and tetrahydroharmine).  Harmine and harmaline are visionary at high levels, but at a modest dosage typically produce mainly tranquility and nausea.  Tetrahydroharmine is present at significant levels in ayahuasca, which may be responsible for some of its more profound effects.

Even though all ayahuasca vines are botanically classified as Banisteriopsis caapi, the curanderos classify them further, in reference to their effects. An example is Cielo Ayahuasca, which means Sky or Heaven Ayahuasca, implying that its effect is of bringing one to celestial realms. Ayahuasca Negra, or Black Ayahuasca, would be used to work specifically with darker energies, shadow selves, or black magic.

Harmala alkaloids have the unique effect of temporarily reducing levels of monoamine oxidase in the body. Monoamine oxidase is an enzyme that normally breaks down tryptamine alkaloids, among others. Monoamine oxidase inhibitors (MAOIs) thus make tryptamines orally active. Therefore, ayahuasca plays an essential role in the brew, opening the door for a host of powerful alkaloids to reach the brain before eventually being broken down by other means.

The principal tryptamine found in ayahuasca is DiMethyltryptamine or DMT. This naturally-occurring biochemical substance is believed to be secreted by the human brain in the pineal gland, especially when dreaming.  Rick Strassman, author of ‘DMT Spirit Molecule’ theorized that 49 days into the development of the human embryo, the pineal gland produces a much larger amount of dimethyltryptamine than normal.  The only other time this occurs naturally is at the moment of our death.  Therefore, Strassman concluded that the production of DMT is a chemical expression of a spiritual event, namely the entering and exiting of the spirit into and from the physical body.  dimethyltryptamine can be found in countless plants and animal species throughout the world.

While some scientists might describe the Ayahuasca experience as merely an oral DMT experience activated by a beta-carboline MAO inhibitor, this description is not accurate. The dynamics of the ayahuasca experience are far more complex, due at least in part to the ayahuasca vine itself which is often said to lend ‘wisdom’ to the experience. This idea is supported by nearly every culture that uses ayahuasca in the Amazon Rainforest.  The truth is that ayahuasca forms part of a complex healing phenomenon that is multifaceted and mysterious and which defies reductive, chemical, or scientific over-simplifications. Ayahuasca is not just a ‘drug’ or ‘medicine’ that acts on a passive recipient; it is a relationship involving many factors, including the intention of the drinker, and the role of the curandero, who uses his/her experience and relationship with the spirit of ayahuasca (as well as other plants) to increase, decrease, and guide the depth of the healing.

Here is a quote from Richard Evans Schultes, one of the earliest pioneers in ayahuasca research, describing the effects of drinking a brew made only from the vine without any admixture plant:


“To this day, the natives of the north-west Amazon in Brazil and Colombia use the Banisteriopsis drink for prophetic and divinatory purposes and also to fortify the bravery of male adolescents about to undergo the severely painful "YURUPARI CEREMONY" for initiation into manhood. The narcosis amongst these people, with whom I have taken caapi on many occasions, is usually pleasant, characterized by visual hallucinations in color, which initially is very often a shade of blue or purple. In excessive doses, it is said to bring on frighteningly nightmarish visions and a feeling of extremely reckless abandon, although consciousness is not lost nor is the use of the limbs unduly affected”.


Effects of Ayahuasca


For millennia, the science of healing has been evolving in the Amazon, passed on orally from generation to generation, and through the plants themselves. The sacred medicine is primarily used to heal, and patients often feel the following effects:


Healing the Body

Nearly everyone describes a physical cleansing or purification process, often involving vomiting or purging. Another name for the brew is ‘la purga’ because of its powerful purgative effects. It is not necessary to throw up, however, and the curandero rarely throws up when leading a ceremony.

Healing the Mind

It is not uncommon to experience a regression back to the situation or the source of a problem or trauma. To relive the experience is to gain new understanding and insights enabling resolution or closure. Dream-like scenes where personal messages from spirits are received cause ceremony participants to re-evaluate their life course with a deeper understanding of why they are here, and what it is they need to do to fulfill their purpose.

Healing the Soul

Most people who experience Ayahuasca report some sort of spiritual experience. Unfortunately, it is very difficult to describe the spiritual effects due to the lack of spirit in our language. Western culture is simply ignorant of the science of spirit that is still practiced today in the Amazon, but it is common for people to feel something that could be described as spiritual.

The quintessential Ayahuasca experience cannot be fully realized outside the natural and cultural environment of the Amazon.  The reason is simple… all the inherently natural organic and cultural links are present. Here the spiritual connection between the plants and human culture which brought the unique brew into existence is strongest and most profound. That the Amazonian plants exist in a spiritual dimension in their natural habitat is evident to those who have experienced ayahuasca both in and out of the Amazon rainforest.  This is not to say, of course, that highly beneficial personal results cannot be achieved using Ayahuasca in other areas of the world.

Ayahuasca Dose, Dosage & Safety

We know you have many important safety questions about Ayahuasca and we are here to answer them. These are normal concerns for anyone considering coming to an Ayahuasca ceremony. Side effects are varied; it depends on the person and the medications being taken.


Diabetics MUST continue taking their medicine before, during, and after a shamanic plant medicine ceremony. So must anyone with high blood pressure medicine and also anyone who takes medicine for their heart.


If You Won’t Ride A Rollercoaster…


One rule of thumb to go by as far as physical conditions go (like heart conditions, high blood pressure, or respiratory issues) is: If you won’t ride a roller coaster, don’t partake in plant medicine ceremonies. People with heart conditions and high blood pressure are at particular risk with plant medicines.

Medicinal Plants, Conventional Drugs and Pharmaceutical Medications Don't Mix!

You CAN be harmed if you are taking certain pharmaceutical drugs in combination with Ayahuasca, particularly antidepressants (SSRIs, SNRIs, MAOIs) and even over-the-counter drugs like cold medicines with ephedrine or caffeine in them. It is important that you do your research and follows directions for stopping these pharmaceutical medicines before taking Ayahuasca.


Consult with your doctor about reversal MAOI or serotonin syndrome concerning Ayahuasca. The time needed for these pharmaceuticals to disperse from your system varies for every person, do your research about the medications you are taking to see if it will be ok with Ayahuasca. Very important!


For the most part, ALL medicines, vitamins, and herbs should be stopped about 2 weeks before partaking in a ceremony, just to be safe. Even seemingly harmless substances should be stopped. The truth is, there are no studies to show what Ayahuasca works with or not, so assume that everything must be stopped for a couple of weeks before an Ayahuasca ceremony.


The information stated on this page on the benefits of indigenous ancestral alternative medicine have not been and will never be evaluated by the Food and Drug Administration, simply because they will never be in favor of it. Therefore, this method of assisted personal self-healing it is not officially considered to diagnose, treat, cure or prevent any disease.

Be also advised that the content of this website is provided for informational purposes only, for open-minded recipients, and not from official medical advisers who only prescribe pharmaceutical medications. It is recommended to consult a professional who has wide knowledge of both, conventional and alternative medicine before the beginning of any natural program.

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